产品编号：X746255

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	X746255
名称:	XL888
别名:	N1-[(3-endo)-8-[5-(Cyclopropylcarbonyl)-2-pyridinyl]-8-azabicyclo[3.2.1]oct-3-yl]-2-methyl-5-[[(1R)-1-methylpropyl]amino]-1,4-benzenedicarboxamide
CAS号:	1149705-71-4
分子式:	C₂₉H₃₇N₅O₃
分子量:	503.64
类别:	Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
应用:	XL888, is a heat shock protein 90 (Hsp90) inhibitor. HSP90, is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.1 XL888 is an ATP-competitive inhibitor of Hsp90.2 Through this action, specific client proteins are degraded, resulting in cell cycle arrest or apoptosis.3,4,5 XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice
参考文献	Haarberg, H. E. et al.: Mol Cancer Ther. 2013 Jun;12(6):901-12.; Paraiso, K. H. et al.: Clin Cancer Res. 2012 May 1;18(9):2502-14.