产品编号：T897135

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	T897135
名称:	Tubulysin A
别名:	(αS,​γR)​-γ-​[[[2-​[(1R,​3R)​-​1-​(Acetyloxy)​-​4-​methyl-​3-​[[(2S,​3S)​-​3-​methyl-​2-​[[[(2R)​-​1-​methyl-​2-​piperidinyl]​carbonyl]​amino]​-​1-​oxopentyl]​[(3-​methyl-​1-​oxobutoxy)​methyl]​amino]​pentyl]​-​4-​thiazolyl]​carbonyl]​amino]​-​4-​hydroxy-​α-​methyl-benzenepentanoic Acid;
CAS号:	205304-86-5
分子式:	C₄₃H₆₅N₅O₁₀S
分子量:	844.07
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
应用:	Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (VIP(LA)I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
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