产品编号：T345135

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	T345135
名称:	1,3-Thiazol-5-ylmethyl N-[(1S)-1-((4S,6S)-4-Benzyl-2-oxo-1,3-oxazinan-6-yl)-2-phenylethyl]carbamate
别名:	N-​[(1S)​-​2-​Phenyl-​1-​[(4S,​6S)​-​tetrahydro-​2-​oxo-​4-​(phenylmethyl)​-​2H-​1,​3-​oxazin-​6-​yl]​ethyl]​-​Carbamic Acid 5-​Thiazolylmethyl Ester
CAS号:	1010809-52-5
分子式:	C₂₄H₂₅N₃O₄S
外观:	Yellow Solid
分子量:	451.54
溶解度:	Dichloromethane;
类别:	Building Blocks; Chiral Molecules;
应用:	1,3-Thiazol-5-ylmethyl N-[(1S)-1-((4S,6S)-4-Benzyl-2-oxo-1,3-oxazinan-6-yl)-2-phenylethyl]carbamate is an intermediate in synthesizing Bis(thiazol-5-yl-methyl)[carbonylbis[imino[(2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-5,2-diyl]]]dicarbamate (R535035). Ritonavir Impurity P is derived from 2S,3S,5S-5-Amino-2-[N-[[(5-thiozolyl)methoxy]carbonyl]amino]-1,6-diphenyl-3-hydroxyhexane (A630525), which is an intermediate in the synthesis of Ritonavir (R535000), a selective HIV protease inhibitor.w
参考文献	Kempf, D., et al.: J. Med. Chem., 41, 602 (1998); Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003); Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005); Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006)