产品编号：T294795

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	T294795
名称:	3a,4,5,6-Tetrahydro-1H,3H-naphtho[1,8-cd]pyran-1-one
CAS号:	81603-30-7
分子式:	C₁₂H₁₂O₂
分子量:	188.22
类别:	Building Blocks; Miscellaneous;
应用:	3a,4,5,6-Tetrahydro-1H,3H-naphtho[1,8-cd]pyran-1-one is an intermediate in the synthesis of (S,S)-Palonosetron Acid which is an impurity in the synthesis of (S,S) Palonosetron (P165800), serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
参考文献	Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),