产品编号：T292310
产品规格：2.5mg
产品价格：面议
| 标准品编号: | T292310 |
| 名称: | 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride |
| 别名: | SIS 3 |
| CAS号: | 521984-48-5 |
| 分子式: | C₂₈H₂₈ClN₃O₃ |
| 外观: | Yellow Solid |
| 熔点: | >161°C (dec.) |
| 分子量: | 489.99 |
| 储存: | -20°C Freezer |
| 溶解度: | Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated) |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)-β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and TGF-β2-induced endothelial cell differentiation in iPSCs (1,2). |
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