产品编号：S687560

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	S687560
名称:	Streptonigrin from Streptomyces flocculus (racemic)
别名:	5278RP; AO 50165L302; Abbott Crystalline antibiotic; Bruneomycin; NSC 45383; NSC 56748; NSC 83950; Nigrin; Rufocromomycin; SN; STP; Streptonigran; Streptonigrin; 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid;
CAS号:	1079893-79-0
分子式:	C₂₅H₂₂N₄O₈
分子量:	506.46
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
应用:	Streptonigrin is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by Streptonigrin are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated. Streptonigrin from Streptomyces flocculus.
参考文献	Donohoe, T., et. al.: J. Org. Chem., 78, 12338 (2013);