产品编号：S199900
产品规格：100mg
产品价格：面议
| 标准品编号: | S199900 |
| 名称: | SC-514 |
| 别名: | 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide; 4-Amino-[2,3'-bithiophene]-5-carboxamide; |
| CAS号: | 354812-17-2 |
| 分子式: | C₉H₈N₂OS₂ |
| 外观: | Yellow Solid |
| 熔点: | 209-211°C |
| 分子量: | 224.3 |
| 溶解度: | DMSO |
| 类别: | Research Tools; Molecular Biology; Enzyme Activators and Inhibitors; |
| 应用: | A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. |
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