产品编号：R925200

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	R925200
名称:	RWJ-67657
别名:	4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol; 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(4-Pyridyl)imidazole; JNJ 3026582; RWJ 67657;
CAS号:	215303-72-3
分子式:	C₂₇H₂₄FN₃O
分子量:	425.5
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflammatory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells,
参考文献	Fijen, J. et al.: Clin. Exp. Immunol., 124, 16 (2001); Westra, J. et al.: Int. Immunopharmacol., 5, 1259 (2005); Westra, J. et al.: Ann. Rheum. Dis., 63, 1453 (2004);