产品编号：R701525

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	R701525
名称:	Ruboxistaurin Hydrochloride
别名:	(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride; LY 333531 Hydrochloride;
CAS号:	169939-93-9
参考CAS号:	Free Base: 169939-94-0
分子式:	C₂₈H₂₉ClN₄O₃
分子量:	505.01
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.
参考文献	Miller, J., et al.: Diabetes Metab. Rev., 13, 37 (1997), Suzuma, I., et al.: J. Biol. Chem., 277, 1047 (2002), Ali, N., et al.: J. Pharmacol. Sci., 98, 130 (2005),