产品编号：R637502

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	R637502
名称:	Ro 106-9920-d5
别名:	6-[(Phenyl-d5)sulfinyl]tetrazolo[1,5-b]pyridazine;
参考CAS号:	62645-28-7-unlabelled
分子式:	C₁₀H₂D₅N₅OS
分子量:	250.29
类别:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
参考文献	Leslie, C., et al.: J. Biol. Chem., 272, 16709 (1997), Liu, F., et al.: Thromb. Res., 106, 199 (2002), Swinney, et al.: J. Biol. Chem., 277, 23573 (2002), Adler, D., et al.: J. Clin. Invest., 118, 2121 (2008),