产品编号：R318535

产品规格：10mg

产品价格：面议

---

产品详情

标准品编号:	R318535
名称:	Rhein Methylate 3-(2,3,4,6-Tetraacetate β-D-Glucopyranose)
别名:	(2R,3R,4S,5R,6S)-2-(Acetoxymethyl)-6-((8-hydroxy-3-(methoxycarbonyl)-9,10-dioxo-9,10-dihydroanthracen-1-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
分子式:	C₃₀H₂₈O₁₅
外观:	Yellow Solid
分子量:	628.53
溶解度:	Dichloromethane, Ethyl Acetate
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Rhein Methylate 3-(2,3,4,6-Tetraacetate β-D-Glucopyranose) is an intermediate in synthesizing Rhein 8-Glucoside (R318520), which has been seen to exhibit cytotoxic and DNVIP(LA)damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants.
参考文献	Wanitschke, Pharmacology, 20, Suppl. 1, 21 (1980); Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982); Franchi-Micheli, S., et al.: J. Pharm. Pharmacol., 35, 262 (1983); Li, S. et al.: J. Asian Nat. Prod. Res., 8, 281 (2006); Shi, Y.Q. et al.: Anticancer. Res., 21, 2847 (2001)