产品编号：R318525

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	R318525
名称:	Rhein Methylate
别名:	Rhein Methyl Ester; 4,5-Dihydroxy-2-anthraquinonecarboxylic Acid Methyl Ester; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid Methyl Ester; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic Acid Methyl Ester
CAS号:	6155-37-9
分子式:	C₁₆H₁₀O₆
外观:	Orange Solid
分子量:	298.25
溶解度:	Dichloromethane, DMF, DMSO
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Rhein Methylate is an intermediate in synthesizing Rhein 8-Glucoside (R318520), which has been seen to exhibit cytotoxic and DNVIP(LA)damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants.
参考文献	Wanitschke, Pharmacology, 20, Suppl. 1, 21 (1980); Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982); Franchi-Micheli, S., et al.: J. Pharm. Pharmacol., 35, 262 (1983); Li, S. et al.: J. Asian Nat. Prod. Res., 8, 281 (2006); Shi, Y.Q. et al.: Anticancer. Res., 21, 2847 (2001);