产品编号：R139300
产品规格：2.5mg
产品价格：面议
| 标准品编号: | R139300 |
| 名称: | Rebastinib |
| 别名: | DCC-2036; DP 1919; 4-[4-[(5-tert-Butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide |
| CAS号: | 1020172-07-9 |
| 分子式: | C₃₀H₂₈FN₇O₃ |
| 外观: | 白色固体 |
| 熔点: | >181°C (dec.) |
| 分子量: | 553.59 |
| 储存: | -20°C Freezer |
| 溶解度: | Methanol (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | Rebastinib shows the selectivity for growth inhibition of Bcr-Abl-positive cells by its marked inhibition of CML cell lines compared to non-CML leukemia lines. Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1. |
| 参考文献 | |
