产品编号：P998435

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P998435
名称:	D-Phenylalanine-bortezomib
别名:	((R)-3-Methyl-1-((S)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid;
分子式:	C₂₈H₃₄BN₅O₅
分子量:	531.41
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	D-Phenylalanine-bortezomib is an impurity of Bortezomib (B675700), which is the first proteasome inhibitor drug used to treat cancer in humans. It is related to stereoisomer N-(2-Pyrazinylcarbonyl)-L-phenylalanyl-N-[(1R)-1-borono-3-methylbutyl]-L-phenylalaninamide (P841515) which is a tripeptide boronic acid proteasome inhibitor used as an antitumor agent.
参考文献	Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009); Zhu, Y., et al.: Bioorg. Med. Chem., 17, 6851 (2009);