产品编号：P338500

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	P338500
名称:	PhiKan-083 Hydrochloride
别名:	9-Ethyl-N-methyl-9H-carbazole-3-methanamine Hydrochloride;
CAS号:	1050480-30-2
参考CAS号:	Free Base: 880813-36-5
分子式:	C₁₆H₁₉ClN₂
分子量:	274.79
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PhiKan-083 is a p53 stabilizing agent. PhiKan-083 preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. PhiKan-083 slows rate of thermal denaturation of p53-Y220C.
参考文献	Vousden, K., et al.: Nat. Rev. Cancer., 2, 594 (2002); Olivier, M., et al.: Hum. Mutat., 19, 607 (2002); Ang, H., et al.: J. Biol. Chem., 281, 21934 (2006); Wiman, et al.: Oncogene, 29, 4245 (2010);