产品编号：P336315

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	P336315
名称:	α-Phenyl-N-(phenylmethyl)benzenemethanamine Hydrochloride
别名:	1,1,1'-Triphenyldimethylamine Hydrochloride
CAS号:	23934-60-3
参考CAS号:	Free Base: 5669-43-2
分子式:	C₂₀H₂₀ClN
外观:	白色固体
分子量:	309.83
溶解度:	Ethanol, Methanol
类别:	Building Blocks; Miscellaneous;
应用:	α-Phenyl-N-(phenylmethyl)benzenemethanamine Hydrochloride is an impurity of 1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride (P309050), which is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence.
参考文献	Naito, R., et al.: J. Med. Chem., 48, 6597 (2005); Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005); Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)