产品编号：P294480

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P294480
名称:	PHVIP(LA)793887
别名:	3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide;
CAS号:	718630-59-2
分子式:	C₁₉H₃₁N₅O₂
外观:	白色至淡黄色固体
熔点:	>147°C (dec.)
分子量:	361.48
储存:	Hygroscopic, 冰箱, under inert atmosphere
溶解度:	DMSO (Slightly), Methanol(Slightly)
稳定性:	Hygroscopic
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PHVIP(LA)793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHVIP(LA)793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHVIP(LA)793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.
参考文献	Alzani, R. et al.: Exp. Hematol., 38, 259 (2010); Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010); Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010);