产品编号：P294400

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P294400
名称:	PHVIP(LA)543613 Dihydrochloride
别名:	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide Dihydrochloride;PHA 543613E;
CAS号:	478148-58-2
参考CAS号:	free base: 478149-53-0
分子式:	C₁₅H₁₉Cl₂N₃O₂
外观:	Tan Solid
熔点:	>300˚C
分子量:	344.24
储存:	冰箱
溶解度:	DMSO, Methanol
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PHVIP(LA)543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer′s disease. PHVIP(LA)543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.
参考文献	Shaffer, C.L. et al.: Drug Metab. Dispos., 35, 1188 (2007); Wishka, D.G. et al.: J. Med. Chem., 49, 4425 (2006); Acker, B.A. et al.: Bioorg. Med. Chem. Lett., 18, 3611 (2008);