产品编号：P293962

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P293962
名称:	PF 670462-d11
别名:	4-[1-(Cyclohexyl-d11)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride;
CAS号:	1794885-93-0
参考CAS号:	类似: 950912-80-8
分子式:	C₁₉H₁₁D₁₁Cl₂FN₅
分子量:	421.38
类别:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Labelled analogue of PF 670462, a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.
参考文献	Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):