产品编号：P293960

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P293960
名称:	PF 670462
别名:	4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride;
CAS号:	950912-80-8
参考CAS号:	freebase: 950980-98-0
分子式:	C₁₉H₂₂Cl₂FN₅
外观:	白色固体
熔点:	>178°C (dec.)
分子量:	410.32
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Very Slightly)
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.
参考文献	Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):