产品编号：P293825

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P293825
名称:	PF-3644022
别名:	(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one;
CAS号:	1276121-88-0
分子式:	C₂₁H₁₈N₄OS
外观:	白色至Yellow Solid
熔点:	>180°C (dec.)
分子量:	374.46
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Slightly)
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
参考文献	Hegen, M., et al.: J. Immunol., 177, 1913 (2006), Anderson, D., et al.: J. Med. Chem., 50, 2647 (2007), Goldberg, D., et al.: Bioorg. Med. Chem. Lett., 18, 938 (2008), Burnette, B., et al.: Pharmacology, 84, 42 (2009), Mourey, et al.: J. Pharmacol. Exp. Ther., 333, 797 (2010),