产品编号：P227455

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	P227455
名称:	trans-2-Pentenoic Acid Chloride
别名:	(2E)-2-Pentenoyl Chloride; (E)-2-Pentenoyl Chloride; (E)-Pent-2-enoyl Chloride; trans-2-Pentenoyl Chloride;
CAS号:	33698-85-0
分子式:	C₅H₇ClO
分子量:	118.56
类别:	Building Blocks; Miscellaneous;
应用:	trans-2-Pentenoic Acid Chloride is an intermediate useful in the synthesis of (1S,2R)-Tapentadol Hydrochloride (T007225), which is the (1S,2R)-isomer of Tapentadol (T007200, HCl); a novel, centrally acting oral analgesic with a dual mode of action that has demonstrated efficacy in preclinical and clinical models of pain relief.
参考文献	Znaleziona, J., et al.: J. Pharmaceut. Biomed., 105, 10 (2015); Boxenbaum, H., et al.: J. Pharm. Sci., 2, 47 (1999); Boase, S., et al.: Br. J. Clin. Pharmacol., 54, 493 (2002); Armstrong, S., et al.: Psychosomatics, 44, 515 (2003); Bjornsson, T., et al.: Drug Metab. Dispos., 31, 815 ( 2003)