产品编号：P218100

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	P218100
名称:	PD-184161
别名:	5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide;
CAS号:	212631-67-9
分子式:	C₁₇H₁₃BrClF₂IN₂O₂
外观:	白色固体
熔点:	174-176°C
分子量:	557.56
储存:	冰箱
溶解度:	DMSO (Slightly), Methanol (Slightly, Heated)
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PD-184161 is a novel mitogen-activated protein kinase kinase (MEK) inhibitor shown to exhibit antitumor effects and suppress MEK-extracellular signal-related kinase signaling activity and cell proliferation in human hepatocellular carcinoma cells and in human hepatocellular carcinoma xenografts.
参考文献	Yip-Schneider, M.T. et al.: J. Pharmacol. Exp. Therap., 329, 1063 (2009); Klein, P.J. et al.: Neoplasia, 8, 1 (2006); Yung, H.W. et al.: Biochem. Pharmacol., 68, 351 (2004);