产品编号：P217600

产品规格：100mg

产品价格：面议

---

产品详情

标准品编号:	P217600
名称:	PD-169316
别名:	4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine; 4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]pyridine;
CAS号:	152121-53-4
分子式:	C₂₀H₁₃FN₄O₂
分子量:	360.34
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membrane tetraspanin. Studies show that PD 169316 reduces myocardial ischemia/reperfusion induced voltage-dependent anion channel(VDAC) phosphorylation
参考文献	Fu, Y. et al.: Bioche,. Biophys. Res. Comm., 310, 391 (2003); Krishnamoorthy, M. et al.: J. Biochem., 145, 177 (2009); Schwertz, H. et al.: Proteomics, 7, 24 (2007);