产品编号：P167502

产品规格：

产品价格：面议

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产品详情

标准品编号:	P167502
名称:	Pamapimod-d4
别名:	6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one-d4; R 1503-d4; Ro 4402257-d4;
CAS号:	1246814-57-2
参考CAS号:	449811-01-2-unlabelled
分子式:	C₁₉H₁₆D₄F₂N₄O₄
分子量:	410.41
类别:	Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Labelled Pamapimod. A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.
参考文献	Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),