产品编号：O249505

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	O249505
名称:	OICR 0547
别名:	1,6-Dihydro-N-[4-(4-morpholinyl)-3'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-yl]-6-oxo-4-(trifluoromethyl)-3-pyridinecarboxamide
CAS号:	1801873-49-3
分子式:	C₂₈H₂₉F₃N₄O₄
分子量:	542.55
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	OICR 0547, is a derivative of OICR-9429 (O249500), which is a chemical probe which inhibits the interaction of WDR5 (WD-repeat Protein 5) with peptide regions of MLL and Histone 3 with high selectivity. WDR5 is a part of the mixed-lineage leukemia (MLL) transferase complex that targets histone 3.
参考文献	Migliori, V. et al.: Epigenetics, 7, 815 (2012); Guccione, E.: Nature, 449, 933 (2007);