产品编号：N900430

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	N900430
名称:	MIRVIP(LA)1
别名:	N-(Propionyloxymethyl)maleimide; NSC 19630; 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;
CAS号:	72835-26-8
分子式:	C₈H₉NO₄
分子量:	183.16
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	The tumor suppressor gene, p53, is often mutated in most human cancers. MIRVIP(LA)1 is a maleimide-derived molecule that can reactivate the mutant p53 leading to apoptosis in human tumor cells. In addition, the MIRA scaffold is an attractive lead for developing anticancer drugs that target mutant p53.
参考文献	Bkov, V. J. et al.: J. Biol. Chem 34, 30384 (2005); Wassman, C. D., et al.: Nat Commun 4, 1407 (2013)