产品编号：N633000

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	N633000
名称:	NO-Aspirin 1
别名:	2-Acetyloxybenzoic Acid 3-Nitrooxymethylphenyl Ester; 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate; NCX 4016;
CAS号:	175033-36-0
分子式:	C₁₆H₁₃NO₇
外观:	白色至白色固体
熔点:	61-62°C
分子量:	331.28
储存:	-20°C Freezer
溶解度:	Chloroform (Slightly), Ethyl Acetate (Slightly)
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.
参考文献	Wallace, J.F., et al.: Drug Development Res., 42, 144 (1997), Takeuchi, K, et al.: J. Physiol. Pharmacol., 49, 501 (1998), Bak, A.W., et al.: Life Sci., 62, 367 (1998), Wallace, J.L., et al.: Nature Reviews Drug Discovery, 1, 375 (2002), Chiroli, V., et al.: Eur. J. Med. Chem., 38, 441 (2003)

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