产品编号：N515275

产品规格：5g

产品价格：面议

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产品详情

标准品编号:	N515275
名称:	2-Nitroisophthalic Acid
别名:	-Nitro-1,3-benzenedicarboxylic Acid; 2-Nitroisophthalic Acid; 3-Carboxy-2-nitrobenzoic Acid
CAS号:	21161-11-5
分子式:	C₈H₅NO₆
外观:	淡黄色固体
分子量:	211.13
溶解度:	Dichloromethane, Ethyl Acetate, Methanol
种类:	Building Blocks; Miscellaneous;
应用:	2-Nitroisophthalic Acid is an intermediate in the synthesis of 2,6-Dihydroxymethyl Rilpivirine (D446615), which is an analog of Rilpivirine (R509800) a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
参考文献	Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001); Griffin, D. et al.: J. Am. Chem. Soc., 134, 13103 (2012);