产品编号：N497030

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	N497030
名称:	N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
CAS号:	1256490-31-9
分子式:	C₁₈H₂₁N₂O₇P
分子量:	408.34
溶解度:	Dichloromethane, Ethyl Acetate, Methanol
种类:	Standards; Chiral Molecules; Amino Acids; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
参考文献	Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)