产品编号：N480992

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	N480992
名称:	1,4-O-Didesmethyl rac-Niranthin-d4
别名:	(2R,3R)-rel-2-[(3,4-dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-1,4-butanediol-d4; (R*,R*)-2-[(3,4-Dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-1,4-butanediol-d4; (R*,R*)-(±)-2-[(3,4-Dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-1,4-butanediol-d4;
参考CAS号:	Unlabelled: 81263-83-4
分子式:	C₂₂H₂₄D₄O₇
分子量:	408.48
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Labelled 1,4-O-Didesmethyl rac-Niranthin is an intermediate in the synthesis of rac-Niranthin (N481000), a lignan compound isolated from the plant Phyllanthus amarus and shows anti-leishmanial activity. It acts through induction of topoisomerase I-mediated DNVIP(LA)protein adduct formation in Leishmania cells triggering apoptosis of cellular nucleases. It also maintains the ability to reduce uric acid concentrations through xanthine oxidase inhibition.
参考文献	Schneiders, G. et al.: Org. Prep. Proc. Int., 14, 1 (1982); Chowdhury, S. et al.: EMBO Mol. Med., 4, 1126 (2012); Murugaiyah, V. et al.: J. Ethnopharm., 124, 233 (2009);