产品编号：N394020

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	N394020
名称:	NIH-12848
别名:	N-(Thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine; N-(2-Thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-4-quinazolinamine;
CAS号:	959551-10-1
分子式:	C₂₀H₁₄F₃N₃S
分子量:	385.41
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.
参考文献	Clarke, J. H., et al.: Biochem. Journal, 466, 359 (2015); Dexheimer, T. S., et al.: J. Med. Chem., 57, 8099 (2014)