产品编号：N381255

产品规格：500µg

产品价格：面议

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产品详情

标准品编号:	N381255
名称:	3-hexanoyl-NBD Cholesterol
别名:	Cholest-5-en-3-ol (3β)-6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoate
CAS号:	201731-19-3
分子式:	C₃₉H₅₈N₄O₅
分子量:	662.9
种类:	Research Tools; Molecular Biology; Fluorescent Reagents; Lipids/Fatty Acids, Glycerol Derivatives; Steroids;
应用:	3-hexanoyl-NBD Cholesterol is a fluorescently-tagged cholesterol derivative with hydrophilic NBD fluorophore attached to carbon 3, at the hydrophilic end of cholesterol, separated by a 6-carbon spacer. This allows the cholesterol to orient in membrane bilayers while the fluorescent tag is presented outside the bilayer. This should model the behavior of cholesterol in membranes better than the previously-used 25-NBD cholesterol, which positions NBD directly on the 25th carbon of cholesterol at the hydrophobic terminus. Fluorescently-tagged lipids are used to study their interactions with proteins, their utilization by cells, and liposomes, and for the development of assays for lipid metabolism.
参考文献	1 Kumagai, K., Yasuda, S., Okemoto, K., et al. CERT mediates intermembrane transfer of various molecular species of ceramides. J Biol Chem 280(8) 6488-6495 (2005). 2 Luo, M., Jones, S.M., Peters-Golden, M., et al. Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc Natl Acad Sci USA 100(21) 12165-12170 (2003). 3 Moreno, M.J., Estronca, L.M.B.B., Vaz, W.L.C. Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes. Biophys J 91 873-881 (2006). 4 Loidl, A., Claus, R., Deigner, H.P., et al. High-precision fluorescence assay for sphingomyelinase activity of isolated enzymes and cell lysates. J Lipid Res 43 815-823 (2002). 5 Tani, M., Okino, N., Mitsutake, S., et al. Specific and sensitive assay f