产品编号：M493185

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	M493185
名称:	N-Methyl Naltrexone Sulfate
别名:	(5α)-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-17-methyl-6-oxo-3-(sulfooxy)-morphinanium
CAS号:	1067643-19-9
分子式:	C₂₁H₂₅NO₇S
分子量:	435.49
种类:	Standards; Molecular Biology; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; Controlled Substances and Drugs of Abuse for Forensic Testing; Opiates;
应用:	N-Methyl Naltrexone Sulfate is a metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
参考文献	Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)