产品编号：M425035

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	M425035
名称:	MK-2461
别名:	N-((2R)-1,4-Dioxan-2-ylmethyl)-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide
CAS号:	917879-39-1
分子式:	C₂₄H₂₅N₅O₅S
分子量:	495.55
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	MK-2461 is a novel ATP-competitive multitargeted kinase inhibitor that preferentially inhibits the activated c-Met receptor. MK-2461 is also a potent inhibitor of Ron, Flt1, Flt 3, PDGFRβ, and Mer receptors. Recent studies show that MK-2461 siginifciantly suppresses tumor growth of GTL-16 xenografts in mice and MK-2461 treatments effectively inhibit the growth of NIH3T3 tumors harboring c-Met single nucleotide mutants T3936C and T3997C.
参考文献	Pan, B.S. et al.: Cancer Res., 70, 1524 (2010); Park, Y.W. et al.: Anal. Biochem., 269, 94 (1999);