产品编号：M289790

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	M289790
名称:	N-(4-methylbenzenesulfonamide) Tolafentrine
别名:	N-(4-((4aS,10bR)-8,9-Dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)phenyl)-4-methyl-N-tosylbenzenesulfonamide
分子式:	C₃₅H₃₇N₃O₆S₂
外观:	淡黄色固体
分子量:	659.81
溶解度:	Dichloromethane, Ethyl Acetate, Methanol
种类:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-(4-methylbenzenesulfonamide) Tolafentrine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
参考文献	Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),