产品编号：125591
产品规格：1MG
产品价格：23,345.00
产品详情
VcMMAE, ≥99%
Product Name： VcMMAE
CAS号:646502-53-6
分子式:C68H105N11O15
分子量:1316.63
贮存： 储存温度-20°C
可溶性： DMSO
生化和生理学机理：
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.
