产品编号：M199503

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	M199503
名称:	MCOPPB Trihydrochloride
别名:	1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole trihydrochloride; 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole Hydrochloride (1:3)
CAS号:	1108147-88-1
参考CAS号:	Free Base: 1028969-49-4
分子式:	C₂₆H₄₀N₄ • 3(HCl)
分子量:	408.6233646
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	MCOPPB Trihydrochloride is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
参考文献	Hayashi, S.; et al.: J. Med. Chem., 52, 610 (2009); Hayashi, S. et al.: J. Med. Chem., 52, 610 (2009); Hirao, A. et al.: J . Pharmacol. Sci., 106, 361 (2008);