产品编号：M199500

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	M199500
名称:	MCOPPB Trihydrochloride
别名:	1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole TriHydrochloride; PF-01678059;
CAS号:	1108147-88-1
参考CAS号:	freeamine: 1028969-49-4
分子式:	C₂₆H₄₃Cl₃N₄
外观:	白色固体
熔点:	>249°C (dec.)
分子量:	518.01
溶解度:	Chloroform, Methanol
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	A potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
参考文献	Hayashi, S. et al.: J. Med. Chem., 52, 610 (2009); Hirao, A. et al.: J . Pharmacol. Sci., 106, 361 (2008);