产品编号：L469445
产品规格：5mg
产品价格：面议
| 标准品编号: | L469445 |
| 名称: | Lonafarnib |
| 别名: | 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; Sarasar; Sch 66336; |
| CAS号: | 193275-84-2 |
| 分子式: | C₂₇H₃₁Br₂ClN₄O₂ |
| 外观: | 白色至白色固体 |
| 熔点: | 150-152°C |
| 分子量: | 638.82 |
| 储存: | 冰箱 |
| 溶解度: | Chloroform (Slightly), Methanol (Slightly) |
| 种类: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells |
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