产品编号：L469308

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	L469308
名称:	LM22B-10
别名:	2,2',2'',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis[ethanol]
CAS号:	342777-54-2
分子式:	C₂₇H₃₃ClN₂O₄
分子量:	485.01
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	LM22B-10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.
参考文献	Yang, Tao., et al.: Neuropharmacology 110, 343 (2016); Huang, Hao-Shun., et al.:‎Antivir. Res.,93,280(2012)