产品编号：L469060

产品规格：2.5g

产品价格：面议

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产品详情

标准品编号:	L469060
名称:	Lithiodiisopropylamine
别名:	Lithium Diisopropylamide; Lithium Diisopropylamine; N-(1-Methylethyl)-2-propanamine Lithium Salt; N-Lithiodiisopropylamide; (Diisopropylamino)lithium; LDA; LDA (reagent); (Diisopropylamino)lithium; Diisopropylamine Lithium Salt;
CAS号:	4111-54-0
参考CAS号:	108-18-9
分子式:	C₆H₁₄LiN
分子量:	107.12
种类:	Building Blocks; Miscellaneous;
应用:	Lithiodiisopropylamine is used in the synthesis and application as initiators of ε-caprolactone polymerization; Also, it is an intermediate used in the synthesis of (3S,5S)-Atorvastatin Sodium Salt (A791735), which is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
参考文献	Mankaev, B. N., et al.: Russ. Chem. Bull., 67, 542-547 (2018); Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18. 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)