产品编号：L469020

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	L469020
名称:	Linsitinib
别名:	cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol; OSI 906; OSI 906AA;
CAS号:	867160-71-2
分子式:	C₂₆H₂₃N₅O
外观:	Pale Yellow to 淡黄色固体
熔点:	>175°C (dec.)
分子量:	421.49
储存:	冰箱
溶解度:	DMSO (Slightly), Methanol (Slightly, Heated)
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Linsitinib is a small-molecule dual insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor. IGF-I receptor (IGF-IR) has been implicated in the promotion of tumorigenesis, metastasis and resistance to cancer therapies and thus Linsitinib may be a useful anticancer agent. Potent IGF-1R inhibitor.
参考文献	Mulvihill, M.M.J. et al.: Fut. Med. Chem., 1, 1153 (2009); Flanigan, S.A. et al.: Clin. Cancer Res., 16, 5436 (2010); McKinley, E.T. et al.: Clin. Cancer Res., 17, 3332 (2011);