产品编号：L178545

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	L178545
名称:	(S)-Laudanosine (S)-α-Hydroxybenzeneacetate
别名:	(S)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline (S)-α-Hydroxy-benzeneacetic Acid;
参考CAS号:	R Isomer: 54677-47-3
分子式:	C₂₁H₂₇NO₄ • C ₈H₈O₃
分子量:	357.4415215
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(S)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline (S)-α-Hydroxybenzeneacetate is an intermediate used in the synthesis of (S)-Laudanosine (L178525), which is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.
参考文献	Canfell, P., et al.: Drug Metab. Dispos., 14, 703 (1986), Anselmi, E., et al.: J. Pharm. Pharmacol., 44, 337 (1992), Bohrer, H., et al.: Pharmacol. Toxicol., 73, 137 (1993)