产品编号：J212505

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	J212505
名称:	JNJ-38877605
别名:	6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline; JNJ 38877605
CAS号:	943540-75-8
分子式:	C₁₉H₁₃F₂N₇
分子量:	377.35
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	JNJ-38877605 is a potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.
参考文献	De Bacco, Francesca., et l.: J Natl Cancer Inst., 103,645 (2011); Cepero, Virna., et al.: Cancer Res., 70,7580 (2010); Basilico, Cristina., et al.: Clin Cancer Res., 19,2381 (2013)