产品编号：J211963
产品规格：25mg
产品价格：面议
| 标准品编号: | J211963 |
| 名称: | JC-1 Chloride |
| 别名: | 6-Dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-1H-benzimidazolium Chloride |
| CAS号: | 34444-93-4 |
| 参考CAS号: | 3520-43-2: Iodide |
| 分子式: | C₂₅H₂₇Cl₄N₄ • Cl |
| 分子量: | 525.323545 |
| 种类: | Research Tools; Molecular Biology; Fluorescent Reagents; Vitamin K Derivatives/Menaquinone; |
| 应用: | JC-1 chloride is a mitochondrial stain. JC-1 chloride is a very sensitive fluorescent probe for testing Pgp activity. Capable of distinguishing between resistant, intermediate and sensitve groups, whereas rhodamine 123 only recognizes the resistent group. In cell lines, the red emission band is more convenient for detection of low-level resistance in AML than other probes, such as rhodamine 123 (529nm) or calcein-AM (517nm). Green fluorescent JC-1 existing as a monomer (λem=527nm) at low concentrations or at low membrane potential. However, at higher concentrations (aqueous solutions above 0.1µM) or higher potentials, JC-1 forms red fluorescent 'J-aggregates', which exhibit a broad excitation spectrum and a very narrow emission spectrum (λem=590nm). JC-1 stains mitochondria in living ce |
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