产品编号：J211325

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	J211325
名称:	JW-55
别名:	N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;
CAS号:	664993-53-7
分子式:	C₂₅H₂₆N₂O₅
分子量:	434.48
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.
参考文献	Waaler, et al., et al.: Cancer Res., 72, 2822 (2012);