产品编号：J210300

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	J210300
名称:	J 147
别名:	2,2,2-Trifluoroacetic Acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide;
CAS号:	1146963-51-0
分子式:	C₁₈H₁₇F₃N₂O₂
分子量:	350.33
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
参考文献	Chen, J., et al.: J. Neurosci., 25, 2366 (2005), Maher, P., et al.: Brain Res., 1173, 117 (2007), Liu, Y., et al.: J. Neurochem., 105, 1336 (2008), Herrup, K., et al.: J. Neurosci., 30, 16755 (2010);