产品编号：I941805

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	I941805
名称:	exo-IWR-1
别名:	rel-4-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide;
CAS号:	1127442-87-8
分子式:	C₂₅H₁₉N₃O₃
分子量:	409.44
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	exo-IWR-1 is the enantiomer of IWR-1 (I941800). exo-IWR-1 is an SAR anticancer Wnt response inhibitor. Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
参考文献	Lepourcelet, M., et al.: Cancer Cell, 5, 91 (2004), Barker, N., et al.: Nat. Rev. Drug Disc., 5, 997 (2006), Clevers, H., et al.: Cell, 127, 469 (2006), Jin, G., et al.: Bioorg. Med. Chem. Lett., 19, 606 (2009),