产品编号：I748570

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	I748570
名称:	IQ 1
别名:	2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide; 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide;
CAS号:	331001-62-8
分子式:	C₂₁H₂₂N₄O₂
分子量:	362.42
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.
参考文献	Kanai., et al.: The Pharmacogenomics J., 4, 336 (2004), Miki., et al.: Stem Cells, 23, 1549 (2005), T. Miyabayashi, et al.: Proc. Natl. Acad. Sci., 104, 5668 (2007), Luo., et al.: Ann. Neurol., 65, 520 (2009),